Archive of Paper of the Week
Masters EA, Ricciardi BF, Bentley KLM, Moriarty TF, Schwarz EM, Muthukrishnan G.Nat Rev Microbiol.
2022 Jul;20(7):385-400. doi: 10.1038/s41579-022-00686-0. Epub 2022 Feb 15.PMID: 35169289
Free PMC article. Review.
Abstract
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many organisms are linked to skeletal infections, Staphylococcus aureus remains the most prevalent and devastating causative pathogen. Important discoveries have uncovered novel mechanisms of S. aureus pathogenesis and persistence within bone tissue, including implant-associated biofilms, abscesses and invasion of the osteocyte lacuno-canalicular network. However, little clinical progress has been made in the prevention and eradication of skeletal infection as treatment algorithms and outcomes have only incrementally changed over the past half century. In this Review, we discuss the mechanisms of persistence and immune evasion in S. aureus infection of the skeletal system as well as features of other osteomyelitis-causing pathogens in implant-associated and native bone infections. We also describe how the host fails to eradicate bacterial bone infections, and how this new information may lead to the development of novel interventions. Finally, we discuss the clinical management of skeletal infection, including osteomyelitis classification and strategies to treat skeletal infections with emerging technologies that could translate to the clinic in the future.
© 2022. Springer Nature Limited.
Periprosthetic joint infections: state-of-the-art
2024 Dec 18;145(1):58. doi: 10.1007/s00402-024-05627-5.
Periprosthetic joint infections: state-of-the-art
Thorsten Gehrke 1, Mustafa Citak 1, Javad Parvizi 2, Nicolaas Cyrillus Budhiparama 3, Mustafa Akkaya 4 5
Affiliations Expand
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PMID: 39694911
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DOI: 10.1007/s00402-024-05627-5
Abstract
In general, periprosthetic joint infection (PJI) is regarded as one of the most common complications of total joint arthroplasty (TJA) and may lead to surgical failure, revision surgery, amputation or death. Nowadays, PJI has become a global health concern, which brings a great burden to public healthcare. In addition, there are still obstacles to achieve high success rates in the prevention, diagnosis and treatment of PJI. However, promising studies are also available with the advancements in biotechnology. This article will present an overview of the current methods used in the prevention, diagnosis and management of PJI while underlining the new technologies utilized.
Keywords: Arthroplasty; Joint replacement; Periprosthetic joint infection.
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Niv Marom, MD , Milan Kapadia, BS, Joseph T. Nguyen, MPH , Brittany Ammerman, MBS, Isabel Wolfe, BS, Kristin C. Halvorsen, BS, Andy O. Miller, MD, Michael W. Henry, MD , Barry D. Brause, MD, Jo A. Hannafin, MD, Robert G. Marx, MD, and Anil S. Ranawat, MDdoi: https://doi.org/10.1177/03635465221078311
Tyler J Humphrey, BA; Alexander M Tatara, MD, PhD; Hany S Bedair, MD; Kyle Alpaugh, MD; Christopher M Melnic, MD; Sandra B Nelson, MDdoi: https://doi.org/10.1016/j.arth.2022.07.018
Anderson DR, Dunbar M, Murnaghan J, et al. Aspirin or rivaroxaban for VTEprophylaxis after hip or knee arthroplasty. New England Journal of Medicine. 2018;378(8):699-707.
Anderson DR, Dunbar M, Murnaghan J, et al. Aspirin or rivaroxaban for VTEprophylaxis after hip or knee arthroplasty. New England Journal of Medicine. 2018;378(8):699-707.
Preobrazhensky P, Bozhkova S, Kochish A, Tikhilov R, Kazemirsky A. Comparative analysisof pathogen structure in patients with PJI after primary total hip and knee arthroplasty.Archives of Orthopaedic and Trauma Surgery 2021 Nov; 141(11) : 1963-1969.
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